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Article

CRISPR/Cas9-Mediated Gene Editing in Human iPSC-Derived Macrophage Reveals Lysosomal Acid Lipase Function in Human Macrophages-Brief Report.

Arteriosclerosis, thrombosis, and vascular biology - 1 Nov 2017

Zhang Hanrui, Shi Jianting, Hachet Melanie A, Xue Chenyi, Bauer Robert C, Jiang Hongfeng, Li Wenjun, Tohyama Junichiro, Millar John, Billheimer Jeffrey, Phillips Michael C, Razani Babak, Rader Daniel J, Reilly Muredach P

Abstract excerpt

OBJECTIVE: To gain mechanistic insights into the role of LIPA (lipase A), the gene encoding LAL (lysosomal acid lipase) protein, in human macrophages. APPROACH AND RESULTS: We used CRISPR (clustered regularly interspaced short palindromic repeats)/Cas9 (CRISPR-associated protein 9) technology to knock out LIPA in human induced pluripotent stem cells and then differentiate to macrophage (human-induced pluripotent...

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Identifiers

PMID: 28882870
DOI: 10.1161/ATVBAHA.117.310023
PMCID: PMC5659288

Genes

LIPA
ABCA1
CCL5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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