Article
Spatial gene expression analysis of neuroanatomical differences in mouse models.
NeuroImage - 1 Dec 2017
Fernandes Darren J, Ellegood Jacob, Askalan Rand, Blakely Randy D, Dicicco-Bloom Emanuel, Egan Sean E, Osborne Lucy R, Powell Craig M, Raznahan Armin, Robins Diane M, Salter Michael W, Sengar Ameet S, Veenstra-VanderWeele Jeremy, Henkelman R M, Lerch Jason P
Abstract excerpt
MRI is a powerful modality to detect neuroanatomical differences that result from mutations and treatments. Knowing which genes drive these differences is important in understanding etiology, but candidate genes are often difficult to identify. We tested whether spatial gene expression data from the Allen Brain Institute can be used to inform us about genes that cause neuroanatomical differences. For many...
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