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Article

Co-expression of Lgr5 and CXCR4 characterizes cancer stem-like cells of colorectal cancer.

Oncotarget - 6 Dec 2016

Wu Weidong, Cao Jun, Ji Zhengyi, Wang Jingjue, Jiang Tao, Ding Honghua

Abstract excerpt

Therapies designed to target cancer stem cells (CSCs) in colorectal cancer (CRC) may improve treatment outcomes. Different markers have been used to identify CSCs or CSC-like cells in CRC, but the enrichment of CSCs using these markers has yet to be optimized. We recently reported the importance of Lgr5-positive CRC cells in cancer growth. Here, we studied the possibility of using Lgr5 and CXCR4 as CSC markers...

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Source

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Identifiers

PMID: 27835894
DOI: 10.18632/oncotarget.13214
PMCID: PMC5348382

Genes

CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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