Article
Pathogen lineage-based genome-wide association study identified CD53 as susceptible locus in tuberculosis.
Journal of human genetics - 1 Dec 2017
Omae Yosuke, Toyo-Oka Licht, Yanai Hideki, Nedsuwan Supalert, Wattanapokayakit Sukanya, Satproedprai Nusara, Smittipat Nat, Palittapongarnpim Prasit, Sawanpanyalert Pathom, Inunchot Wimala, Pasomsub Ekawat, Wichukchinda Nuanjun, Mushiroda Taisei, Kubo Michiaki, Tokunaga Katsushi, Mahasirimongkol Surakameth
Abstract excerpt
Tuberculosis (TB) is known to be affected by host genetic factors. We reported a specific genetic risk factor through a genome-wide association study (GWAS) that focused on young age onset TB. In this study, we further focused on the heterogeneity of Mycobacterium tuberculosis (M. tb) lineages and assessed its possible interaction with age at onset on host genetic factors. We identified the pathogen lineage in...
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