Article
A next generation sequencing combined genome-wide association study identifies novel tuberculosis susceptibility loci in Chinese population.
Genomics - 1 Jul 2021
Li Mo, Hu Yi, Zhao Baihui, Chen Luan, Huang Hailiang, Huai Cong, Zhang Xiaoqing, Zhang Jinghong, Zhou Wei, Shen Lu, Zhen Qi, Li Bao, Wang Wenjun, He Lin, Qin Shengying
Abstract excerpt
The genetic factors of tuberculosis (TB) susceptibility have been widely recognized. Here we performed a two-stage study in 616 TB patients and 709 healthy controls to systematically identify the genetic markers of TB susceptibility. In the discovery stage, we identified 93 single nucleotide polymorphisms (SNPs) and 3 human leucocyte antigen (HLA) class II alleles that had potential associations with TB...
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