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Genome-wide association studies of tuberculosis in Asians identify distinct at-risk locus for young tuberculosis.

Journal of human genetics - 1 Jun 2012

Mahasirimongkol Surakameth, Yanai Hideki, Mushiroda Taisei, Promphittayarat Watoo, Wattanapokayakit Sukanya, Phromjai Jurairat, Yuliwulandari Rika, Wichukchinda Nuanjun, Yowang Amara, Yamada Norio, Kantipong Patcharee, Takahashi Atsushi, Kubo Michiaki, Sawanpanyalert Pathom, Kamatani Naoyuki, Nakamura Yusuke, Tokunaga Katsushi

Abstract excerpt

Tuberculosis (TB) is one of the most devastating chronic infectious diseases, but the role of host genetics in disease development after infection in this disease remains unidentified. Genome-wide association studies (GWASs) in Thais and Japanese were carried out and separately analyzed, attempted replication, then, combined by meta-analysis were not yielding any convincing association evidences; these results...

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Identifiers

PMID: 22551897
DOI: 10.1038/jhg.2012.35

Genes

MAFB
TNF

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