Carbonyl reductase 1 catalyzes 20β-reduction of glucocorticoids, modulating receptor activation and metabolic complications of obesity.

doi:10.1038/s41598-017-10410-1

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Article

Carbonyl reductase 1 catalyzes 20β-reduction of glucocorticoids, modulating receptor activation and metabolic complications of obesity.

Scientific reports - 6 Sept 2017

Morgan Ruth A, Beck Katharina R, Nixon Mark, Homer Natalie Z M, Crawford Andrew A, Melchers Diana, Houtman René, Meijer Onno C, Stomby Andreas, Anderson Anna J, Upreti Rita, Stimson Roland H, Olsson Tommy, Michoel Tom, Cohain Ariella, Ruusalepp Arno, Schadt Eric E, Björkegren Johan L M, Andrew Ruth, Kenyon Christopher J, Hadoke Patrick W F, Odermatt Alex, Keen John A, Walker Brian R

Abstract excerpt

Carbonyl Reductase 1 (CBR1) is a ubiquitously expressed cytosolic enzyme important in exogenous drug metabolism but the physiological function of which is unknown. Here, we describe a role for CBR1 in metabolism of glucocorticoids. CBR1 catalyzes the NADPH- dependent production of 20β-dihydrocortisol (20β-DHF) from cortisol. CBR1 provides the major route of cortisol metabolism in horses and is up-regulated in...

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PMID: 28878267
DOI: 10.1038/s41598-017-10410-1
PMCID: PMC5587574

Genes

CBR1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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