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Article

Human carbonyl reductase 1 participating in intestinal first-pass drug metabolism is inhibited by fatty acids and acyl-CoAs.

Biochemical pharmacology - 15 Aug 2017

Hara Akira, Endo Satoshi, Matsunaga Toshiyuki, El-Kabbani Ossama, Miura Takeshi, Nishinaka Toru, Terada Tomoyuki

Abstract excerpt

Human carbonyl reductase 1 (CBR1), a member of the short-chain dehydrogenase/reductase (SDR) superfamily, reduces a variety of carbonyl compounds including endogenous isatin, prostaglandin E2 and 4-oxo-2-nonenal. It is also a major non-cytochrome P450 enzyme in the phase I metabolism of carbonyl-containing drugs, and is highly expressed in the intestine. In this study, we found that long-chain fatty acids and...

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Source

Identifiers

PMID: 28450226
DOI: 10.1016/j.bcp.2017.04.023

Genes

CBR1
CBR3
DCXR
DHRS4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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Human carbonyl reductase 1 participating in intestinal first-pass drug metabolism is inhibited by fatty acids and acyl-CoAs.PMID 28450226Read ↗

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