Expression Profiles of Glucocorticoid Receptor α- and β-Isoforms in Diverse Physiological and Pathological Conditions

Abstract excerpt

Through alternative splicing, two isoforms of the glucocorticoid receptor (GR) gene are generated, termed GRα and GRβ. GRα is predominantly expressed and shows steroid binding activity, whereas GRβ is thought to be inactive as a result of its truncated ligand-binding domain. GRβ may only act as a dominant negative inhibitor when co-expressed with GRα. GRβ specifically binds RU486 and also exhibits intrinsic...

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