The Pumilio-domain protein PUF6 contributes to SIDER2 retroposon-mediated mRNA decay in Leishmania

Abstract excerpt

Leishmania and other trypanosomatid protozoa lack control at the level of transcription initiation and regulate gene expression exclusively post-transcriptionally. We have reported previously that Leishmania harbors a unique class of s hort i nterspersed de generate r etroposons (SIDERs) that are predominantly located within 3′UTRs and play a major role in post-transcriptional control. We have shown that members...

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