Article
Exonuclease-mediated degradation of nascent RNA silences genes linked to severe malaria.
Nature - 18 Sept 2014
Zhang Qingfeng, Siegel T Nicolai, Martins Rafael M, Wang Fei, Cao Jun, Gao Qi, Cheng Xiu, Jiang Lubin, Hon Chung-Chau, Scheidig-Benatar Christine, Sakamoto Hiroshi, Turner Louise, Jensen Anja T R, Claes Aurelie, Guizetti Julien, Malmquist Nicholas A, Scherf Artur
Abstract excerpt
Antigenic variation of the Plasmodium falciparum multicopy var gene family enables parasite evasion of immune destruction by host antibodies. Expression of a particular var subgroup, termed upsA, is linked to the obstruction of blood vessels in the brain and to the pathogenesis of human cerebral malaria. The mechanism determining upsA activation remains unknown. Here we show that an entirely new type of gene...
Topics
- Alleles
- Antigenic Variation
- Chromatin
- Down-Regulation
- Erythrocytes
- Exoribonucleases
- Gene Silencing
- Genes, Protozoan
- Humans
- Introns