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Unmasking the causes of multifactorial disorders: OXPHOS differences between mitochondrial haplogroups.

Human molecular genetics - 1 Sept 2010

Gómez-Durán Aurora, Pacheu-Grau David, López-Gallardo Ester, Díez-Sánchez Carmen, Montoya Julio, López-Pérez Manuel J, Ruiz-Pesini Eduardo

Abstract excerpt

Many epidemiologic studies have associated human mitochondrial haplogroups to rare mitochondrial diseases like Leber's hereditary optic neuropathy or to more common age-linked disorders such as Parkinson's disease. However, cellular, biochemical and molecular-genetic evidence that is able to explain these associations is very scarce. The etiology of multifactorial diseases is very difficult to sort out because...

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PMID: 20566709
DOI: 10.1093/hmg/ddq246

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Unmasking the causes of multifactorial disorders: OXPHOS differences between mitochondrial haplogroups.PMID 20566709Read ↗

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