Article
Cytotoxicity of replication-competent adenoviruses powered by an exogenous regulatory region is not linearly correlated with the viral infectivity/gene expression or with the E1A-activating ability but is associated with the p53 genotypes.
BMC cancer - 5 Sept 2017
Yamauchi Suguru, Zhong Boya, Kawamura Kiyoko, Yang Shan, Kubo Shuji, Shingyoji Masato, Sekine Ikuo, Tada Yuji, Tatsumi Koichiro, Shimada Hideaki, Hiroshima Kenzo, Tagawa Masatoshi
Abstract excerpt
BACKGROUND: Replication-competent adenoviruses (Ad) produced cytotoxic effects on infected tumors and have been examined for the clinical applicability. A biomarkers to predict the cytotoxicity is valuable in a clinical setting. METHODS: We constructed type 5 Ad (Ad5) of which the expression of E1A gene was activated by a 5' regulatory sequences of survivin, midkine or cyclooxygenase-2, which were highly...
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