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Article

Development of a highly sensitive liquid biopsy platform to detect clinically-relevant cancer mutations at low allele fractions in cell-free DNA.

PloS one - 1 Jan 2018

Gale Davina, Lawson Andrew R J, Howarth Karen, Madi Mikidache, Durham Bradley, Smalley Sarah, Calaway John, Blais Shannon, Jones Greg, Clark James, Dimitrov Peter, Pugh Michelle, Woodhouse Samuel, Epstein Michael, Fernandez-Gonzalez Ana, Whale Alexandra S, Huggett Jim F, Foy Carole A, Jones Gerwyn M, Raveh-Amit Hadas, Schmitt Karin, Devonshire Alison, Green Emma, Forshew Tim, Plagnol Vincent, Rosenfeld Nitzan

Abstract excerpt

INTRODUCTION: Detection and monitoring of circulating tumor DNA (ctDNA) is rapidly becoming a diagnostic, prognostic and predictive tool in cancer patient care. A growing number of gene targets have been identified as diagnostic or actionable, requiring the development of reliable technology that provides analysis of multiple genes in parallel. We have developed the InVision™ liquid biopsy platform which utilizes...

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Cell-Free Nucleic Acids
Circulating Tumor DNA
DNA, Neoplasm
High-Throughput Nucleotide Sequencing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoplastic Cells, Circulating

Reproducibility of Results

Sensitivity and Specificity

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Identifiers

PMID: 29547634
DOI: 10.1371/journal.pone.0194630
PMCID: PMC5856404

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