Article
Analytical and clinical validation of a custom 15-gene next-generation sequencing panel for the evaluation of circulating tumor DNA mutations in patients with advanced non-small-cell lung cancer.
PloS one - 1 Jan 2022
Chow Yock Ping, Zainul Abidin Norziha, Kow Ken Siong, Tho Lye Mun, Wong Chieh Lee
Abstract excerpt
BACKGROUND: This is a pilot proof-of-concept study to evaluate the utility of a custom 15-gene circulating tumor DNA (ctDNA) panel as a potential companion molecular next-generation sequencing (NGS) assay for identifying somatic single nucleotide variants and indels in non-small-cell lung cancer (NSCLC) patients. The custom panel covers the hotspot mutations in EGFR, KRAS, NRAS, BRAF, PIK3CA, ERBB2, MET, KIT,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.