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Article

Pharmacogenomic Variability of Oral Baclofen Clearance and Clinical Response in Children With Cerebral Palsy.

PM & R : the journal of injury, function, and rehabilitation - 1 Mar 2018

McLaughlin Matthew J, He Yang, Brunstrom-Hernandez Janice, Thio Liu Lin, Carleton Bruce C, Ross Colin J D, Gaedigk Andrea, Lewandowski Andrew, Dai Hongying, Jusko William J, Leeder J Steven

Abstract excerpt

BACKGROUND: Pharmacogenomic variability can contribute to differences in pharmacokinetics and clinical responses. Pediatric patients with cerebral palsy with genetic variations have not been studied for these potential differences. OBJECTIVE: To determine the genetic sources of variation in oral baclofen clearance and clinical responses. DESIGN: Pharmacogenomic add-on study to determine variability in oral...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28867665
DOI: 10.1016/j.pmrj.2017.08.441
PMCID: PMC5880219

Genes

ABCC12
ABCC9
PPARD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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