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Article

Genotype-dependent response to combined levodopa/benserazide and trihexyphenidyl in pediatric genetic dystonia.

Brain & development - 1 Jun 2026

Zhou Xiaolin, Li Yu, Luo Xiangyang, He Zhanwen, Liu Mujin, Li Pinggan

Abstract excerpt

BACKGROUND: Genetic etiologies underlie a substantial proportion of pediatric dystonia, but whether treatment response to combined dopaminergic and anticholinergic therapy varies by genotype remains unknown. METHODS: This retrospective cohort study analyzed 36 children with genetically confirmed dystonia, classified into three subgroups: PANK2 (n = 7), channelopathies (SCN1A/SCN2A/SCN3A/SCN1B, KCNQ2; n = 6), and...

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Source

Identifiers

PMID: 42119286
DOI: 10.1016/j.braindev.2026.104545

Genes

PANK2
CP
KCNQ2
SCN1A
SCN1B
SCN2A
SCN3A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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