Back to search

Article

<i>ABCB1</i>GENE POLYMORPHISMS ARE ASSOCIATED WITH CLINICAL RESPONSE TO NABIXIMOLS IN PATIENTS WITH MULTIPLE SCLEROSIS-RELATED SPASTICITY

2025-06-20

Abstract excerpt

<h4>Background</h4> Multiple Sclerosis (MS) is an autoimmune disease of the central nervous system causing severe symptoms, including spasticity-related pain. Nabiximols (NBX), a drug combining Tetrahydrocannabinol and Cannabidiol, is approved for MS-associated spasticity. Despite NBX efficacy, only 60-70% of patients respond to treatment. This study explores whether genetic polymorphisms in key genes involved in...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
b5ae7b89-32da-54d8-97e3-84881668f205
DOI
10.1101/2025.06.20.25329925
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
<i>ABCB1</i>GENE POLYMORPHISMS ARE ASSOCIATED WITH CLINICAL RESPONSE TO NABIXIMOLS IN PATIENTS WITH MULTIPLE SCLEROSIS-RELATED SPASTICITYDOI 10.1101/2025.06.20.25329925
Abcb1 Gene Polymorphisms Are Associated With Clinical Response to Nabiximols in Patients With Multiple Sclerosis-related SpasticitySemantic proximity
Single nucleotide polymorphisms in the cannabinoid CB2 receptor: Molecular pharmacology and disease associations.Semantic proximity
Single nucleotide polymorphisms of ABCB1 gene and response to etanercept treatment in patients with ankylosing spondylitis in a Chinese Han population.Semantic proximity
Pharmacogenetics of glatiramer acetate therapy for multiple sclerosis reveals drug-response markers.Semantic proximity
Pharmacogenetic Predictors of Cannabidiol Response and Tolerability in Treatment-Resistant Epilepsy.Semantic proximity
ABCC2 rs2273697, rs717620, rs3740066 Polymorphisms and Antiseizure Medication Resistance: A Systematic Review and Meta-AnalysisSemantic proximity
ABC-transporter gene-polymorphisms are potential pharmacogenetic markers for mitoxantrone response in multiple sclerosis.Semantic proximity
Genetic Polymorphisms, their Allele Combinations and IFN-β Treatment Response in Irish Multiple Sclerosis PatientsSemantic proximity
The (AAT)n repeat of the cannabinoid CB1 receptor gene influences disease progression in relapsing multiple sclerosis.Semantic proximity
Therapeutic Value of Single Nucleotide Polymorphisms on the Efficacy of New Therapies in Patients with Multiple SclerosisSemantic proximity
A pharmacogenetic signature of high response to Copaxone in late-phase clinical-trial cohorts of multiple sclerosis.Semantic proximity
Pharmacogenetics of siponimod: A systematic review.Semantic proximity
Select a neighboring publication to make it the new centre.