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Article

The immunophilin FKBP12 inhibits hepcidin expression by binding the BMP type I receptor ALK2 in hepatocytes.

Blood - 9 Nov 2017

Colucci Silvia, Pagani Alessia, Pettinato Mariateresa, Artuso Irene, Nai Antonella, Camaschella Clara, Silvestri Laura

Abstract excerpt

The expression of the key regulator of iron homeostasis hepcidin is activated by the BMP-SMAD pathway in response to iron and inflammation and among drugs, by rapamycin, which inhibits mTOR in complex with the immunophilin FKBP12. FKBP12 interacts with BMP type I receptors to avoid uncontrolled signaling. By pharmacologic and genetic studies, we identify FKBP12 as a novel hepcidin regulator. Sequestration of...

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Identifiers

PMID: 28864813
DOI: 10.1182/blood-2017-04-780692
PMCID: PMC5755682

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