Hepcidin-induced internalization of ferroportin requires binding and cooperative interaction with Jak2

Abstract excerpt

Hepcidin is a hormone secreted in response to iron loading and inflammation. Hepcidin binds to the iron exporter ferroportin, inducing its degradation and thus preventing iron entry into plasma. We determined that hepcidin binding to ferroportin leads to the binding and activation of the protein Janus Kinase2 (Jak2), which is required for phosphorylation of ferroportin. Ferroportin is a dimer and both monomers...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Erythropoietin and Anemia Treatment
• Share to Hemoglobinopathies and Related Disorders
• Share to Iron Metabolism and Disorders