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Article

BMP type II receptors have redundant roles in the regulation of hepatic hepcidin gene expression and iron metabolism.

Blood - 25 Sept 2014

Mayeur Claire, Leyton Patricio A, Kolodziej Starsha A, Yu Binglan, Bloch Kenneth D

Abstract excerpt

Expression of hepcidin, the hepatic hormone controlling iron homeostasis, is regulated by bone morphogenetic protein (BMP) signaling. We sought to identify which BMP type II receptor expressed in hepatocytes, ActR2a or BMPR2, is responsible for regulating hepcidin gene expression. We studied Bmpr2 heterozygous mice (Bmpr2(+/-)), mice with hepatocyte-specific deficiency of BMPR2, mice with global deficiency of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25075125
DOI: 10.1182/blood-2014-04-572644
PMCID: PMC4186540

Genes

BMPR2
BMP6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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