Soluble Interleukin-7 receptor levels and risk of acute graft-versus-host disease after allogeneic haematopoietic stem cell transplantation.

doi:10.1016/j.clim.2017.08.015

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Article

Soluble Interleukin-7 receptor levels and risk of acute graft-versus-host disease after allogeneic haematopoietic stem cell transplantation.

Clinical immunology (Orlando, Fla.) - 1 Feb 2018

Kielsen Katrine, Shamim Zaiba, Thiant Stephanie, Faucher Sylvie, Decker Wendy, Christensen Ib Jarle, Ryder Lars Peter, Yakoub-Agha Ibrahim, Müller Klaus

Abstract excerpt

Interleukin-7 is a cytokine essential for T cell homeostasis. IL-7 binds to cellular IL-7 receptors in competition with a soluble form of the receptor (sIL-7Rα). We hypothesized that altered sIL-7Rα levels may cause adverse outcomes in patients undergoing HSCT. In parallel, we investigated the impact of the IL-7Rα SNP rs6897932, which has been associated with release of IL-7R. The sIL-7Rα levels decreased during...

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PMID: 28863969
DOI: 10.1016/j.clim.2017.08.015

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