Prognostic significance of interleukin-7 receptor-α gene polymorphisms in allogeneic stem-cell transplantation: a confirmatory study.

doi:10.1097/TP.0b013e31820f08b2

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Article

Prognostic significance of interleukin-7 receptor-α gene polymorphisms in allogeneic stem-cell transplantation: a confirmatory study.

Transplantation - 15 Apr 2011

Shamim Zaiba, Ryder Lars P, Christensen Ib J, Toubert Antoine, Norden Jean, Collin Matthew, Jackson Graham, Dickinson Anne M, Müller Klaus

Abstract excerpt

BACKGROUND: Interleukin-7 (IL-7) is a hematopoietic cytokine essential for T-cell development in the thymus and for the maintenance of peripheral T cells. A previous study of single nucleotide polymorphisms in the exons of IL-7 receptor α-chain (IL-7Rα) in a Danish cohort of patients undergoing allogeneic stem-cell transplantation (SCT) identified donor genotype GG at rs1494555 as a risk factor for...

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PMID: 21326139
DOI: 10.1097/TP.0b013e31820f08b2

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