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Article

PTEN allelic loss is an important mechanism in the late stage of development of oral leucoplakia into oral squamous cell carcinoma.

Histopathology - 1 Jan 2018

Miyahara Ligia A N, Pontes Flávia S C, Burbano Rommel M R, Conte Neto Nicolau, Guimarães Douglas M, Fonseca Felipe P, Pontes Hélder A R

Abstract excerpt

AIM: The aim of this study was to analyse allelic loss of the phosphatase and tensin homologue deleted on chromosome 10 (PTEN) gene and its protein immuno-expression in dysplastic oral lesions and oral squamous cell carcinomas (OSCCs). METHODS AND RESULTS: Samples were collected from 153 patients [20 ranulas used as a control (C); 30 leucoplakias with mild dysplasia (MD); 30 leucoplakias with moderate to severe...

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Share to Carcinoma, Squamous Cell
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Head and Neck Neoplasms

Share to Leukoplakia, Oral

Share to Mouth Neoplasms

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Share to PTEN Phosphohydrolase

Share to Squamous Cell Carcinoma of Head and Neck

Source

Identifiers

PMID: 28858374
DOI: 10.1111/his.13381

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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