Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Loss of alleles of loci on the short arm of chromosome 3 in renal cell carcinoma.

Nature - 1 Jan 2000

Zbar B, Brauch H, Talmadge C, Linehan M

Abstract excerpt

Loss of genes at specific chromosomal loci is a characteristic of retinoblastoma, Wilms' tumour, transitional cell carcinoma of the bladder, embryonal tumours and small cell carcinoma of the lung. The significance of nonrandom gene loss in these neoplasms is that gene loss on one chromosome may uncover null mutations at corresponding loci of the homologous chromosome. Loss of specific gene products from somatic...

Topics

Adult
Aged
Alleles
Carcinoma, Renal Cell
Chromosome Aberrations
Chromosomes, Human, Pair 3
DNA
DNA, Recombinant
Heterozygote
Humans
Kidney Neoplasms
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nucleic Acid Hybridization

Polymorphism, Restriction Fragment Length

Translocation, Genetic

Source

Identifiers

PMID: 2885753
DOI: 10.1038/327721a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2885753-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss of alleles of loci on the short arm of chromosome 3 in renal cell carcinoma.PMID 2885753Read ↗

Molecular analysis of the short arm of chromosome 3 in five renal oncocytomas.Semantic proximity Read ↗

Molecular genetic investigation of sporadic renal cell carcinoma: analysis of allele loss on chromosomes 3p, 5q, 11p, 17 and 22.Semantic proximity Read ↗

[Mapping allelic deletions on the short arm of human chromosome 3 in kidney neoplasms].Semantic proximity Read ↗

Comparative allelotyping of the short arm of human chromosome 3 in epithelial tumors of four different types.Semantic proximity Read ↗

Deletions of the short arm of chromosome 3 in solid tumors and the search for suppressor genes.Semantic proximity Read ↗

Identification of a 700-kb region of common allelic loss in chromosome bands 3p14.3-p21.1 in human renal cell carcinoma.Semantic proximity Read ↗

Loss of heterozygosity of chromosome 3p markers in small-cell lung cancer.Semantic proximity Read ↗

A submicroscopic homozygous deletion at the D3S3 locus in a cell line isolated from a small cell lung carcinoma.Semantic proximity Read ↗

Comprehensive allelotyping of human renal cell carcinomas using microsatellite DNA probes.Semantic proximity Read ↗

Loss of heterozygosity on the short arm of chromosome 3 in mesothelioma cell lines and solid tumors.Semantic proximity Read ↗

Deletion mapping on the short arm of chromosome 3 in squamous cell carcinoma and adenocarcinoma of the lung.Semantic proximity Read ↗

Molecular mapping of deletion sites in the short arm of chromosome 3 in human lung cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.