Elucidation of potential sites for antibody engineering by fluctuation editing.

Abstract excerpt

Target-specific monoclonal antibodies can be routinely acquired, but the sequences of naturally acquired antibodies are not always affinity-matured and methods that increase antigen affinity are desirable. Most biophysical studies have focused on the complementary determining region (CDR), which directly contacts the antigen; however, it remains difficult to increase the affinity as much as desired. While...

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• Share to Antibody Affinity
• Share to Antigens
• Share to Complementarity Determining Regions