Article
Pathophysiological analyses of cortical malformation using gyrencephalic mammals.
Scientific reports - 20 Oct 2015
Masuda Kosuke, Toda Tomohisa, Shinmyo Yohei, Ebisu Haruka, Hoshiba Yoshio, Wakimoto Mayu, Ichikawa Yoshie, Kawasaki Hiroshi
Abstract excerpt
One of the most prominent features of the cerebral cortex of higher mammals is the presence of gyri. Because malformations of the cortical gyri are associated with severe disability in brain function, the mechanisms underlying malformations of the cortical gyri have been of great interest. Combining gyrencephalic carnivore ferrets and genetic manipulations using in utero electroporation, here we successfully...
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