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Article

Structure of eIF4E in Complex with an eIF4G Peptide Supports a Universal Bipartite Binding Mode for Protein Translation.

Plant physiology - 1 Jul 2017

Miras Manuel, Truniger Verónica, Silva Cristina, Verdaguer Núria, Aranda Miguel A, Querol-Audí Jordi

Abstract excerpt

The association-dissociation of the cap-binding protein eukaryotic translation initiation factor 4E (eIF4E) with eIF4G is a key control step in eukaryotic translation. The paradigm on the eIF4E-eIF4G interaction states that eIF4G binds to the dorsal surface of eIF4E through a single canonical alpha-helical motif, while metazoan eIF4E-binding proteins (m4E-BPs) advantageously compete against eIF4G via bimodal...

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Identifiers

PMID: 28522457
DOI: 10.1104/pp.17.00193
PMCID: PMC5490897

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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