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Article

PI3K: A Crucial Piece in the RAS Signaling Puzzle.

Cold Spring Harbor perspectives in medicine - 1 Jun 2018

Krygowska Agata Adelajda, Castellano Esther

Abstract excerpt

RAS proteins are key signaling switches essential for control of proliferation, differentiation, and survival of eukaryotic cells. RAS proteins are mutated in 30% of human cancers. In addition, mutations in upstream or downstream signaling components also contribute to oncogenic activation of the pathway. RAS proteins exert their functions through activation of several signaling pathways and dissecting the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Class I Phosphatidylinositol 3-Kinases

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Source

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Identifiers

PMID: 28847905
DOI: 10.1101/cshperspect.a031450
PMCID: PMC5983164

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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