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Article

RAS Interaction with PI3K: More Than Just Another Effector Pathway

1 Mar 2011

Abstract excerpt

RAS PROTEINS ARE SMALL GTPASES KNOWN FOR THEIR INVOLVEMENT IN ONCOGENESIS: around 25% of human tumors present mutations in a member of this family. RAS operates in a complex signaling network with multiple activators and effectors, which allows them to regulate many cellular functions such as cell proliferation, differentiation, apoptosis, and senescence. Phosphatidylinositol 3-kinase (PI3K) is one of the main...

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PMID: 21779497
DOI: 10.1177/1947601911408079

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