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Article

Genetics of complex traits in psychiatry.

Biological psychiatry - 1 Jan 2015

Gelernter Joel

Abstract excerpt

Virtually all psychiatric traits are genetically complex. This article discusses the genetics of complex traits in psychiatry. The complexity is accounted for by numerous factors, including multiple risk alleles, epistasis, and epigenetic effects such as methylation. Risk alleles can individually be common or rare, and can include, for example, single nucleotide polymorphisms and copy number variants that are...

Topics

Epigenomics
Epistasis, Genetic
Gene-Environment Interaction
Genetic Variation
Genome-Wide Association Study
High-Throughput Nucleotide Sequencing
Humans
Mental Disorders
Pharmacogenetics
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Open in PubMed Open full text

Identifiers

PMID: 25444161
DOI: 10.1016/j.biopsych.2014.08.005
PMCID: PMC4282183

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