Article
Relation of Mycobacterium tuberculosis mutations at katG315 and inhA-15 with drug resistance profile, genetic background, and clustering in Argentina.
Diagnostic microbiology and infectious disease - 1 Nov 2017
Monteserin Johana, Paul Roxana, Latini Cecilia, Simboli Norberto, Yokobori Noemí, Delfederico Lucrecia, López Beatriz, Ritacco Viviana
Abstract excerpt
We analyzed 362 isoniazid-resistant clinical isolates of Mycobacterium tuberculosis obtained countrywide for the presence of mutation at katG315 and inhA-15 in relation to genotype, pattern of phenotypic resistance to other drugs, and ability to spread. We found the following mutation frequencies: katG315MUT/inhA-15wt 53.0%, katG315wt/inhA-15MUT 27.4%, katG315wt/inhA-15wt 19.3%, and katG315MUT/inhA-15MUT only...
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