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Article

The MukB-topoisomerase IV interaction is required for proper chromosome compaction.

The Journal of biological chemistry - 13 Oct 2017

Kumar Rupesh, Nurse Pearl, Bahng Soon, Lee Chong M, Marians Kenneth J

Abstract excerpt

The bacterial condensin MukB and the cellular decatenating enzyme topoisomerase IV interact. This interaction stimulates intramolecular reactions catalyzed by topoisomerase IV, supercoiled DNA relaxation, and DNA knotting but not intermolecular reactions such as decatenation of linked DNAs. We have demonstrated previously that MukB condenses DNA by sequestering negative supercoils and stabilizing topologically...

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Share to Chromosomal Proteins, Non-Histone
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28842485
DOI: 10.1074/jbc.M117.803346
PMCID: PMC5641886

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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