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Article

The MukB-ParC interaction affects the intramolecular, not intermolecular, activities of topoisomerase IV.

The Journal of biological chemistry - 15 Mar 2013

Hayama Ryo, Bahng Soon, Karasu Mehmet E, Marians Kenneth J

Abstract excerpt

Proper chromosome organization is accomplished through binding of proteins such as condensins that shape the DNA and by modulation of chromosome topology by the action of topoisomerases. We found that the interaction between MukB, the bacterial condensin, and ParC, a subunit of topoisomerase IV, enhanced relaxation of negatively supercoiled DNA and knotting by topoisomerase IV, which are intramolecular DNA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23349462
DOI: 10.1074/jbc.M112.418087
PMCID: PMC3597806

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The MukB-ParC interaction affects the intramolecular, not intermolecular, activities of topoisomerase IV.PMID 23349462Read ↗

The MukB-topoisomerase IV interaction is required for proper chromosome compaction.Semantic proximity Read ↗

The bacterial condensin MukB compacts DNA by sequestering supercoils and stabilizing topologically isolated loops.Semantic proximity Read ↗

Partition of P1 plasmids in Escherichia coli mukB chromosomal partition mutants.Semantic proximity Read ↗

The Saccharomyces cerevisiae Smc2/4 condensin compacts DNA into (+) chiral structures without net supercoiling.Semantic proximity Read ↗

Mitotic chromosomes are compacted laterally by KIF4 and condensin and axially by topoisomerase IIα.Semantic proximity Read ↗

Suppression of chromosome segregation defects of Escherichia coli muk mutants by mutations in topoisomerase I.Semantic proximity Read ↗

The "GyrA-box" is required for the ability of DNA gyrase to wrap DNA and catalyze the supercoiling reaction.Semantic proximity Read ↗

MukB colocalizes with the oriC region and is required for organization of the two Escherichia coli chromosome arms into separate cell halves.Semantic proximity Read ↗

SMC is recruited to <i>oriC</i> by ParB and promotes chromosome segregation in <i>Streptococcus pneumoniae</i>Semantic proximity Read ↗

Distinct regions of the Escherichia coli ParC C-terminal domain are required for substrate discrimination by topoisomerase IV.Semantic proximity Read ↗

MobB protein stimulates nicking at the R1162 origin of transfer by increasing the proportion of complexed plasmid DNA.Semantic proximity Read ↗

Silencing of genes flanking the P1 plasmid centromere.Semantic proximity Read ↗

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