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Article

Panel sequencing of 264 candidate susceptibility genes and segregation analysis in a cohort of non-BRCA1, non-BRCA2 breast cancer families.

Breast cancer research and treatment - 1 Dec 2017

Li Jun, Li Hongyan, Makunin Igor, Thompson Bryony A, Tao Kayoko, Young Erin L, Lopez Jacqueline, Camp Nicola J, Tavtigian Sean V, John Esther M, Andrulis Irene L, Khanna Kum Kum, Goldgar David, Chenevix-Trench Georgia

Abstract excerpt

PURPOSE: The main aim of this study was to screen epigenetic modifier genes and known breast cancer driver genes for germline mutations in non-BRCA1/2 (BRCAx) breast cancer families in order to identify novel susceptibility genes of moderate-high penetrance. METHODS: We screened 264 candidate susceptibility genes in 656 index cases from non-BRCA1/2 families. Potentially pathogenic candidate mutations were then...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28840378
DOI: 10.1007/s10549-017-4469-0
PMCID: PMC6238949

Genes

BRCA1
CHD8
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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