Article

Non-BRCA1/BRCA2 High-Risk Familial Breast Cancers are Not Associated with a High Prevalence of BRCAness

2021-08-26

Abstract excerpt

<title>Abstract</title> <p>Familial breast cancer is in most cases unexplained due to the lack of identifiable pathogenic variants in the BRCA1 and BRCA2 genes. Using genome sequencing, we first noted for non-BRCA1/BRCA2 tumours, only a small proportion (3/23) demonstrated features of BRCAness, with high HRDetect scores and concomitant somatic BRCA1 mutation or promoter hypermethylation to explain their BRCAness....

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Literature Corpus work: f48aded1-b75f-5171-b5bd-756cdd04be10
DOI: 10.21203/rs.3.rs-827829/v1

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