Article
An efficient genome-wide association test for mixed binary and continuous phenotypes with applications to substance abuse research.
Statistical methods in medical research - 1 Mar 2018
Buu Anne, Williams L Keoki, Yang James J
Abstract excerpt
We propose a new genome-wide association test for mixed binary and continuous phenotypes that uses an efficient numerical method to estimate the empirical distribution of the Fisher's combination statistic under the null hypothesis. Our simulation study shows that the proposed method controls the type I error rate and also maintains its power at the level of the permutation method. More importantly, the...
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