Article
Analysis of multiple phenotypes in genome-wide genetic mapping studies.
BMC bioinformatics - 2 May 2013
Suo Chen, Toulopoulou Timothea, Bramon Elvira, Walshe Muriel, Picchioni Marco, Murray Robin, Ott Jurg
Abstract excerpt
BACKGROUND: Complex traits may be defined by a range of different criteria. It would result in a loss of information to perform analyses simply on the basis of a final clinical dichotomized affected / unaffected variable. RESULTS: We assess the performance of four alternative approaches for the analysis of multiple phenotypes in genetic association studies. We describe the four methods in detail and discuss their...
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