Epistasis mediates the role of negative frequency-dependent selection in bacterial strain structure.

Abstract excerpt

Strain structure is a well-documented phenomenon in many pathogenic and commensal bacterial species, where distinct strains persist over time exhibiting stable associations between genetic or phenotypic traits. This structure is surprising, particularly in highly recombinogenic species like Streptococcus pneumoniae, because recombination typically breaks down linkage disequilibrium, the non-random association of...

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