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Evaluation of Post‐Mortem Effects on Global Brain DNA Methylation and Hydroxymethylation

20 Aug 2017

Abstract excerpt

The number of epigenetic studies on brain functions and diseases are dramatically increasing, but little is known about the impact of post-mortem intervals and post-sampling effects on DNA modifications such as 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC). Here, we examined post-mortem-induced changes in global brain 5mC and 5hmC levels at post-mortem intervals up to 540 min., and studied effects of...

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PMID: 28834189
DOI: 10.1111/bcpt.12875

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