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Brain-derived cell-free DNA as a marker for neuroapoptosis following prolonged general anesthesia in infants and children: results of the BRAIN study

2026-06-02

Abstract excerpt

<title>Abstract</title> <p>Preclinical studies in rodents and non-human primates demonstrate anesthesia-induced neuroapoptosis in the developing brain. This prompted an FDA black-box warning for anesthetic agents in children <3yrs, despite no robust molecular or clinical data in humans. Here we report results of the BRAIN study, which used validated brain-specific cell-free DNA (cfDNA) methylation biomarkers to d...

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Literature Corpus work
41e51714-ffb2-53d9-9e54-cb5cb661069b
DOI
10.21203/rs.3.rs-9226846/v1
Open publication

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