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Article

Bifunctional quorum-quenching and antibiotic-acylase MacQ forms a 170-kDa capsule-shaped molecule containing spacer polypeptides.

Scientific reports - 21 Aug 2017

Yasutake Yoshiaki, Kusada Hiroyuki, Ebuchi Teppei, Hanada Satoshi, Kamagata Yoichi, Tamura Tomohiro, Kimura Nobutada

Abstract excerpt

Understanding the molecular mechanisms of bacterial antibiotic resistance will help prepare against further emergence of multi-drug resistant strains. MacQ is an enzyme responsible for the multi-drug resistance of Acidovorax sp. strain MR-S7. MacQ has acylase activity against both N-acylhomoserine lactones (AHLs), a class of signalling compounds involved in quorum sensing, and β-lactam antibiotics. Thus, MacQ is...

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Identifiers

PMID: 28827579
DOI: 10.1038/s41598-017-09399-4
PMCID: PMC5566955

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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