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Mapping the Structural Determinants of Quorum Sensing Activity in Streptococcus sinensis Via Mutational Analysis of Its Competence Stimulating Peptide.

Biochemistry - 21 Apr 2026

Renshaw Clay P, Basnet Anju, Yeh Christopher R, Wang Angela, Tal-Gan Yftah

Abstract excerpt

Streptococcus sinensis is an oral commensal bacterium implicated in the severe cardiovascular disease, infective endocarditis. In Mitis group Streptococci, including S. sinensis, colonization, competition, and virulence are regulated by the ComABCDE quorum sensing (QS) system. This pathway depends on secretion of the competence stimulating peptide (CSP), which activates the membrane-bound histidine kinase...

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PMID: 41923425
DOI: 10.1021/acs.biochem.6c00057

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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