Article

Catalytic Redundancies and Conformational Plasticity Drives Selectivity and Promiscuity in Quorum Quenching Lactonases

2024-05-01

Abstract excerpt

Several enzymes from the metallo-β-lactamase-like family of lactonases (MLLs) degrade N- acyl-L-homoserine lactones (AHLs). In doing so, they play a role in a microbial communication system, quorum sensing, which contributes to pathogenicity and biofilm formation. There is currently great interest in designing quorum quenching ( QQ ) enzymes that can interfere with this communication and be used in a range of in...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cbee8603-7b5c-5d27-900f-63ece28735ff
DOI: 10.1101/2024.05.01.592096

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Catalytic Redundancies and Conformational Plasticity Drives Selectivity and Promiscuity in Quorum Quenching LactonasesDOI 10.1101/2024.05.01.592096Read

Structural evidence of a productive active site architecture for an evolved quorum-quenching GKL lactonase.Semantic proximity Read

Structure and mechanism of potent bifunctional β-lactam- and homoserine lactone-degrading enzymes from marine microorganismsSemantic proximity Read

The molecular structure and catalytic mechanism of a quorum-quenching N-acyl-L-homoserine lactone hydrolase.Semantic proximity Read

Evolution of β-lactamases and enzyme promiscuitySemantic proximity Read

Innovative microbial disease biocontrol strategies mediated by quorum quenching and their multifaceted applications: A reviewSemantic proximity Read

Quorum-quenching microbial infections: mechanisms and implicationsSemantic proximity Read

Biodiversity of N-acyl homoserine lactonase (aiiA) gene from Bacillus subtilis.Semantic proximity Read

Applying molecular and phenotypic screening assays to identify efficient quorum quenching lactonases.Semantic proximity Read

Metagenomics revealed a quorum quenching lactonase QlcA from yet unculturable soil bacteria.Semantic proximity Read

Molecular basis for the substrate specificity of quorum signal synthases.Semantic proximity Read

Lactonase-mediated inhibition of quorum sensing largely alters phenotypes, proteome, and antimicrobial activities in Burkholderia thailandensis E264.Semantic proximity Read

AIM‐1: An Antibiotic‐Degrading Metallohydrolase That Displays Mechanistic FlexibilitySemantic proximity Read