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Article

Structure and function of a serine carboxypeptidase adapted for degradation of the protein synthesis antibiotic microcin C7.

Proceedings of the National Academy of Sciences of the United States of America - 20 Mar 2012

Agarwal Vinayak, Tikhonov Anton, Metlitskaya Anastasia, Severinov Konstantin, Nair Satish K

Abstract excerpt

Several classes of naturally occurring antimicrobials exert their antibiotic activity by specifically targeting aminoacyl-tRNA synthetases, validating these enzymes as drug targets. The aspartyl tRNA synthetase "Trojan horse" inhibitor microcin C7 (McC7) consists of a nonhydrolyzable aspartyl-adenylate conjugated to a hexapeptide carrier that facilitates active import into bacterial cells through an oligopeptide...

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Identifiers

PMID: 22388748
DOI: 10.1073/pnas.1114224109
PMCID: PMC3311384

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Source receipt: pubmed, retrieved 7 Sept 2026.

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