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Article

KDM1B is a histone H3K4 demethylase required to establish maternal genomic imprints.

Nature - 17 Sept 2009

Ciccone David N, Su Hui, Hevi Sarah, Gay Frédérique, Lei Hong, Bajko Jeffrey, Xu Guoliang, Li En, Chen Taiping

Abstract excerpt

Differential DNA methylation of the paternal and maternal alleles regulates the parental origin-specific expression of imprinted genes in mammals. The methylation imprints are established in male and female germ cells during gametogenesis, and the de novo DNA methyltransferase DNMT3A and its cofactor DNMT3L are required in this process. However, the mechanisms underlying locus- and parental-specific targeting of...

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Identifiers

PMID: 19727073
DOI: 10.1038/nature08315

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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