Article
Identification of NRAS isoform 2 overexpression as a mechanism facilitating BRAF inhibitor resistance in malignant melanoma.
Proceedings of the National Academy of Sciences of the United States of America - 5 Sept 2017
Duggan Megan C, Stiff Andrew R, Bainazar Maryam, Regan Kelly, Olaverria Salavaggione Gonzalo N, Maharry Sophia, Blachly James S, Krischak Madison, Walker Christopher J, Latchana Nicholas, Tridandapani Susheela, de la Chapelle Albert, Eisfeld Ann-Kathrin, Carson William E
Abstract excerpt
Activating mutations in BRAF are found in 50% of melanomas and although treatment with BRAF inhibitors (BRAFi) is effective, resistance often develops. We now show that recently discovered NRAS isoform 2 is up-regulated in the setting of BRAF inhibitor resistance in melanoma, in both cell lines and patient tumor tissues. When isoform 2 was overexpressed in BRAF mutant melanoma cell lines, melanoma cell...
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