Article
RAF-Mutant Melanomas Differentially Depend on ERK2 Over ERK1 to Support Aberrant MAPK Pathway Activation and Cell Proliferation.
Molecular cancer research : MCR - 1 Jun 2021
Crowe Matthew S, Zavorotinskaya Tatiana, Voliva Charles F, Shirley Matthew D, Wang Yanqun, Ruddy David A, Rakiec Daniel P, Engelman Jeffery A, Stuart Darrin D, Freeman Alyson K
Abstract excerpt
Half of advanced human melanomas are driven by mutant BRAF and dependent on MAPK signaling. Interestingly, the results of three independent genetic screens highlight a dependency of BRAF-mutant melanoma cell lines on BRAF and ERK2, but not ERK1. ERK2 is expressed higher in melanoma compared with other cancer types and higher than ERK1 within melanoma. However, ERK1 and ERK2 are similarly required in primary human...
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