Article

Proteasomal downregulation of the pro-apoptotic MST2 pathway contributes to BRAF inhibitor resistance in melanoma

2022-02-22

Abstract excerpt

The RAS-RAF-MEK-ERK pathway is hyperactivated in almost all malignant melanomas, and mutations in BRAF or NRAS account for most of these cases. BRAF inhibitors are highly efficient for treating patients with BRAF V600E mutations, but tumours frequently acquire resistance within a few months. Multiple resistance mechanisms have been identified, due to mutations or network adaptations that revive ERK signalling. We...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8d746d60-1965-5903-9d68-9105ec4ae6cb
DOI: 10.1101/2022.02.21.481296

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Proteasomal downregulation of the pro-apoptotic MST2 pathway contributes to BRAF inhibitor resistance in melanomaDOI 10.1101/2022.02.21.481296Read

Resistance to BRAF-targeted therapy in melanoma.Semantic proximity Read

Targeting RAF kinases for cancer therapy: BRAF-mutated melanoma and beyond.Semantic proximity Read

Overcoming Resistance to Therapies Targeting the MAPK Pathway in BRAF-Mutated TumoursSemantic proximity Read

BRAF inhibitors: resistance and the promise of combination treatments for melanomaSemantic proximity Read

Molecular pathways: response and resistance to BRAF and MEK inhibitors in BRAF(V600E) tumors.Semantic proximity Read

Overcoming resistance to BRAF inhibitorsSemantic proximity Read

Tumor Cell Resistance to the Inhibition of BRAF and MEK1/2.Semantic proximity Read

Tumor Cell Resistance to the Inhibition of BRAF and MEK1/2Semantic proximity Read

BRAF and MEK Inhibitors: Use and Resistance in BRAF-Mutated Cancers.Semantic proximity Read

A Review of the Molecular Pathways Involved in Resistance to BRAF Inhibitors in Patients with Advanced-Stage Melanoma.Semantic proximity Read

[Resistance to BRAF inhibitors: A lesson from clinical observations].Semantic proximity Read

RAF-Mutant Melanomas Differentially Depend on ERK2 Over ERK1 to Support Aberrant MAPK Pathway Activation and Cell Proliferation.Semantic proximity Read