Article
Resistance mechanisms to genetic suppression of mutant NRAS in melanoma.
Melanoma research - 1 Dec 2017
Robinson James P, Rebecca Vito W, Kircher David A, Silvis Mark R, Smalley Inna, Gibney Geoffrey T, Lastwika Kristin J, Chen Guo, Davies Michael A, Grossman Douglas, Smalley Keiran S M, Holmen Sheri L, VanBrocklin Matthew W
Abstract excerpt
Targeted therapies have revolutionized cancer care, but the development of resistance remains a challenge in the clinic. To identify rational targets for combination strategies, we used an established melanoma mouse model and selected for resistant tumors following genetic suppression of NRAS expression. Complete tumor regression was observed in all mice, but 40% of tumors recurred. Analysis of resistant tumors...
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